The 
program
The science-based program that delivers
weight loss for health gains
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THE OPTIWIN STUDY
OPTIWIN is a year-long, head-to-head study, designed to evaluate the effectiveness of a medically monitored, behavioral, meal replacement weight loss program (the OPTIFAST Program) on weight loss and maintenance, in comparison with a standard-of-care, reduced-energy, food-based diet (modiefied version of Diabetes Prevention Program, DPP) and lifestyle intervention among adults with a BMI higher than 30.
Study Design
Duration
52 weeks: 26-week weight loss phase, followed by a 26-week weight maintenance phase.
How?
Open-label, randomized, controlled trial
Where?
multicenter (9 sites across the U.S.)
Participants
multicenter (9 sites across the U.S.)
Method
(n=135 mITT*)
ACTIVE PHASE:
- Total meal replacement up to 16 weeks
- 800 kcal/day, based on BMI
- 40% carbohydrate, 40% protein, 20% fat
- Gradual introduction of food
MAINTENANCE:
Conventional food, encouraged 1-2 meal replacements per day.
FOOD-BASED PROGRAM
(n=135 mITT*)
ACTIVE PHASE:
- Reduced energy (-500 to -750 kcal/day, 25% to 30% fat) diet based on modified Diabetes Prevention Program for 26 weeks.
MAINTENANCE:
Increased energy intake to achieve weight maintenance.
IN BOTH GROUPS
150-180 minutes per week of moderate to vigorous intensity exercise
Group (weekly) and individual (per schedule) behavioral counseling sessions.
Results
Mean weight loss
Patients lost 2x as much weight using the OPTIFAST® program
Mean change in total fat mass (kg)
OPTIFAST® program patients achieved greatest reductions in total fat mass
Mean change in waist circumference (cm)
Patients experienced greater reductions in waist circumference using the OPTIFAST® program
Sucess Stories
Everyday, OPTIFAST® is helping people like you discover that the benefits of a healthy lifestyle go far beyond weight loss. Find out what real patients have to say about their OPTIFAST® experience.
To my great surprise, when race day came, I found myself ready to go. While it w...
READ MOREWeight Lost 59 lbs*
Emily
In January of 2016 when his on-the-go lifestyle started to show on the scale, Je...
READ MOREWeight Lost 69 lbs*
Jeffrey
When she agreed to attend an OPTIFAST® informational meeting with her parents, s...
READ MOREWeight Lost 52 lbs*
Emily
No one says it better than Tawni: “OPTIFAST® has reset my mind and put me back o...
READ MOREWeight Lost 144 lbs*